We are the cover of Science 2018 Breakthrough of the Year!

The 2018 Breakthrough of the Year by Science Magazine was chosen to be “Development cell by cell”. Amongst other papers this includes the work done by Jeff/Yiqun and Bushra/Jamie on reconstructing cell by cell development in zebrafish which were published earlier this year.

Science Magazine story: https://vis.sciencemag.org/breakthrough2018/

Jeff and Yiqun’s paper: https://www.ncbi.nlm.nih.gov/pubmed/29700225
Bushra and Jamie’s paper: https://www.ncbi.nlm.nih.gov/pubmed/30353175

Tessa's paper published in Development

Our latest paper "Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse" was published in Development.

Nodal signaling is crucial for left-right patterning, however some studies have suggested differences between zebrafish and mouse. In this study, single and double mutants for genes involved in Nodal signaling were generated. Imaging of mutant phenotypes as well as biochemical and activity assays revealed the regulatory logic of this system. These results show that left-right patterning mechanisms are conserved from zebrafish to mouse.

Congratulations Tessa!