How does the brain decide whether an odor is attractive or aversive? In larval zebrafish, Oded Mayseless and co-authors reveal that odor preference is represented by spatially cohesive neuronal domains within the olfactory bulb, in collaboration with the lab of Rainer Friedrich.
Using weMERFISH, Flashseq, CampariSeq, and a custom-built behavioral setup, Oded and authors show that the larval zebrafish olfactory bulb is organized spatially, transcriptionally, and functionally in ways that reflect whether odors are perceived as attractive or aversive. Their work provides new insight into how sensory information is transformed into meaningful behavioral responses.
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