Congratulations Mada and co-authors on their work The regulatory landscape of 5′ UTRs in translational control during zebrafish embryogenesis. Mada used a massively parallel reporter assay (MPRA) of 18,154 RNA sequences to uncover the translation initiation potential of endogenous 5’UTRs by polysome profiling. They look at the regulation across zebrafish embryogenesis (2, 4, 6 and 10 hours post fertilisation). From this data they identified different regulatory dynamics and 86 potential regulatory motifs. Some of motifs are known RNA protein binding motifs, but many are new. This is exciting as each motif is a new lead to find regulatory proteins and further our understanding of how RNA to protein translation is controlled.
Congratulations again to Mada and the team!